Extended neuromuscular blockade with mivacurium following pancuronium
نویسندگان
چکیده
منابع مشابه
Extended neuromuscular blockade with mivacurium following pancuronium.
A 21-year-old female weighing 55 kg was anaesthetized for facial reconstruction. After an initial bolus of pancuronium 5 mg and top-up doses of 2 mg at 135 min and 1 mg at 290 min and 335 min, no further relaxant was given for 130 min at which time neuromuscular transmission appeared fully recovered with a full train-of-four twitches and a sustained response to 50 Hz stimulation of the posterio...
متن کاملInteractions between mivacurium and pancuronium.
We have compared the dose-response relationships of mivacurium, pancuronium and their combination, and examined the interactions by isobolographic and fractional analyses. We studied 70 adult patients during nitrous oxide-fentanyl-propofol anaesthesia. The dose-response curves were determined by probit analysis. The ED95 and ED50 values for mivacurium were 84.2 (95% confidence interval 80.2-88....
متن کاملThe reversal of profound mivacurium-induced neuromuscular blockade.
PURPOSE Mivacurium is metabolized by plasma cholinesterase catalyzed ester hydrolysis. Acetylcholinesterase antagonists used in the reversal of muscle relaxation may also inhibit plasma cholinesterase and, therefore, delay the hydrolysis of mivacurium. The clinical interaction between acetylcholinesterase antagonists and mivacurium induced neuromuscular blockade was studied. METHOD Intraopera...
متن کاملNeostigmine requirements for reversal of neuromuscular blockade following an infusion of mivacurium.
PURPOSE To study the efficacy of neostigmine compared with placebo for the antagonism of neuromuscular blockade at the end of a mivacurium infusion, and to determine its optimal dose. METHODS One hundred adult patients undergoing an elective surgical procedure received a standardized anaesthetic with 20-30 micrograms.kg-1 alfentanil, a propofol infusion and nitrous oxide. Muscle relaxation wa...
متن کاملPotentiation of pancuronium and vecuronium neuromuscular blockade by intravenous salbutamol.
Three doses of salbutamol 125 micrograms iv were given, over 3.5 hr, to a 28-yr-old healthy, previously non-asthmatic man during thiopentone-O2/N2O-isoflurane anaesthesia for treatment and prophylaxis of bronchospasm. Force of contraction of the adductor pollicis was measured before and after the last two injections. Initially, the patient was given pancuronium, 5 mg. Salbutamol, 125 micrograms...
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ژورنال
عنوان ژورنال: European Journal of Anaesthesiology
سال: 1996
ISSN: 0265-0215,1365-2346
DOI: 10.1046/j.1365-2346.1996.00989.x